There are more and more aware and smart people out there seeing more and more clearly that eventually (as you say) "at some point there HAS to be a 9wholesale) disruption of the old system.

Yup ... we'll need new and relevant core assumptions about (interconnected) work, the changes to traditional hierarchy, and the ways we 'manage' in the new context.

I've suggested in the past (as I believe you know) that OD principles are a pretty darned good candidate for a set of new principles and a coherent framework for "management 2.0" or "unmanagement" (pick your label). I haven't yet seen or heard any reasons to change that perspective, IMO.